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...what we do

General Research Interests

Wu laboratory combines neuroscience and systems-based approaches involving genomics, bioinformatics and functional assays to unravel gene transcription and regulatory mechanisms in stem cells and glial cells. One major focus of our group is investigating stem cell neural differentiation and developing effective and safe treatment for spinal cord injury and neurological diseases. We are studying gene expression and the regulation of transcription factors and regulatory RNAs using next-generation sequencing technologies including RNA-Seq, ChIP-Seq, and ATAC-Seq, as well as functional tests. Our goal is to identify novel regulatory mechanisms and key regulators as therapeutic targets for spinal cord injury, and to increase stem cell transplantation safety.

Research Projects

  • Characterize molecular signatures of spinal cord injury and neurological diseases
  • Study astrogliosis and myelination in spinal cord injury and neurological diseases
  • Investigate gene expression during stem cell neural differentiation by RNA-Seq and single cell sequencing Study
  • Pinpoint key transcription factors and regulatory RNAs, and modulate key regulators to steer the direction of stem cell differentiation and improve efficiency
  • Network analysis of stem cell differentiation and global network integration of multiple types of omic data
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