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...what we do

General Research Interests

Wu laboratory combines neuroscience and systems-based approaches involving genomics, bioinformatics and functional assays to unravel gene transcription and regulatory mechanisms in stem cells and glial cells. One major focus of our group is investigating stem cell neural differentiation and developing effective and safe treatment for spinal cord injury and neurological diseases. We are studying gene expression and the regulation of transcription factors and regulatory RNAs using next-generation sequencing technologies including RNA-Seq, ChIP-Seq, and ATAC-Seq etc.. Our goal is to identify novel regulatory mechanisms and key regulators as therapeutic targets for spinal cord injury, and to increase stem cell transplantation safety.

The other area of our research interest lies in the studies of the regulatory networks of precursor cell self-renewal and differentiation using multipotent EML (erythroid, myeloid, and lymphocytic) cell as a model system. We are using integrated genomic and proteomic approaches to identify key components that control the switch. This study can serve as a model for the analysis of cell self-renewal and differentiation in general and provide insight for efficient expanding and manipulating precursor and stem cells.

Research Projects

  • Characterize molecular signatures of spinal cord injury and neurological diseases
  • investigate gene expression during stem cell neural differentiation by RNA-Seq and single cell sequencing
  • Pinpoint key transcription factors and regulatory RNAs, and modulate key regulators to steer the direction of stem cell differentiation and improve efficiency
  • Identify the molecular switch of precursor cell self-renewal and differentiation
  • Network analysis of stem cell differentiation and global network integration of multiple types of omic data
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